I have been having a number of issues with unlocking 1PX ever since desktop app integration was introduced. I have random moments when it just get stuck in an infinite "Connecting to 1Password for Mac" loop, even if I simply unlocked the extension earlier and want to come back and unlock it later on (after a system sleep).
I actually think the latest loop came from 1Password updating to BETA 7. Let me know how to extract logs and where to send them .
1Password Version: 1.15.4
Extension Version: 1Password 7 Version 7.3.BETA-7 (70300007) AgileBit
OS Version: 10.14.4
Sync Type: 1Password