2FA usually works with a username/password response challenge and then asking for the 2nd factor in seperate field, page whatever.
The German provider mailbox.org uses 2FA in a sperate way. First you have to define a PIN code in the settings, e. g. "1234". Then you activate 2FA, scan the QR code with 1Password and turn on the OTP feature.
When you're going to login at mailbox.org you have to enter
(1234 = PIN, 847362 = 2FA-Code)
Can 1Passwd handle this automatically?
1Password Version: 7.3.1
Extension Version: 220.127.116.11
OS Version: 10.14.6
Sync Type: 1Password