Using CleanMyMac2, I found 1.4 GB 1Password in application support that apparently has not been opened in 3 months. Is it safe to delete that? Right below it is "1Password 4" that is 185 MB. I need the space it I can get rid of it.
That sounds like leftover data from 1Password 3. If you're confident that 1Password 4 has enough backups of your data (in case things go wonky), then you can delete that old folder.