Just today I noticed the the 1Password icon in Safari was just a gray box. I can't remember when I used it last in Safari, so I'm not sure if it just disappeared today or I just noticed it now. To get it back, I searched for it in Safari extensions. It had a choice to install it so I installed it. After installing it reappeared, but clicking on it gives the error message shown in the attached image. I completely exited out of Safari and restarted, but I still get the same message. I can open the desktop application fine and the extension works fine in Chrome. My purchase was from agilebits.com rather than the app store.
1Password Version: 3.8.22 build 32010
Extension Version: 4.2.2
OS Version: OS X 10.10.5
Sync Type: Dropbox