It doesn't happen with any discernable steps to reproduce the bug, but when I am using Chrome on occasion I can no longer hover over elements and have the action noticed (by css or JS or whatever) and things that are normally a single click action such as clicking a link require a double click. In most cases it makes websites extremely difficult to navigate. I have narrowed it down by disabling the 1Password extension when it happens and it seems to work just fine.
1Password Version: 1Password 6 Version 6.8.3 (683005) AgileBits Store
Extension Version: 126.96.36.199
OS Version: 10.13
Sync Type: Dropbox
Referrer: forum-search:chrome extension breaks hover state and single click