This issue (or a related one) was first raised in March 2017. It appears to be back, at least for me. I am frequently asked to enable the 1Password Safari extension, usually when I launch Safari for the first time.
I tried uninstalling/rebooting/reinstalling to no avail (although I suspect it wasn't a "clean" uninstall as I was not prompted for my account code the first time I launched 1Password after the reinstall).
Any suggestions for me to try? Thanks.
1Password Version: 7.2.2
Extension Version: 7.2.2
OS Version: macOS 10.14.1
Sync Type: Subscription